| Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne. | |
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MedLine Citation:
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PMID: 17578730 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulation efficiency (EE) of RA in SLN is usually low, unless a high surfactant/lipid ratio is used. The aim of this work was to develop SLN with high EE using a low surfactant/lipid ratio. Different formulations of RA-loaded SLN were prepared using glyceryl behenate as lipid matrix. The particle size, EE, zeta potential and differential scanning calorimetry (DSC) were investigated. High EE in SLN was obtained with addition of amines. These results indicate that the utilization of amines is an interesting approach to improve the EE of RA in SLN using a low surfactant/lipid ratio. |
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Authors:
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Gisele A Castro; Rodrigo L Oréfice; José M C Vilela; Margareth S Andrade; Lucas A M Ferreira |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of microencapsulation Volume: 24 ISSN: 0265-2048 ISO Abbreviation: J Microencapsul Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2008-01-16 Revised Date: 2009-07-21 |
Medline Journal Info:
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Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: England |
Other Details:
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Languages: eng Pagination: 395-407 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy, Department of Pharmaceutics, Federal University Minas Gerais, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy* Administration, Cutaneous Amines / chemistry Calorimetry, Differential Scanning Chemistry, Pharmaceutical Crystallization Delayed-Action Preparations Drug Compounding / methods Drug Delivery Systems* Excipients / chemistry Fatty Acids / chemistry Humans Keratolytic Agents / administration & dosage* Microscopy, Polarization Nanoparticles / chemistry* Octanols / chemistry Particle Size Solubility Static Electricity Tretinoin / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Delayed-Action Preparations; 0/Excipients; 0/Fatty Acids; 0/Keratolytic Agents; 0/Octanols; 18641-57-1/glyceryl behenate; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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