Document Detail

Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne.
MedLine Citation:
PMID:  17578730     Owner:  NLM     Status:  MEDLINE    
The development of solid lipid nanoparticles (SLN) containing all-trans retinoic acid (RA) is an interesting approach to topical treatment of acne. SLN has potential for controlled release and follicular penetration, which can reduce adverse effects in comparison with conventional formulations. However, the encapsulation efficiency (EE) of RA in SLN is usually low, unless a high surfactant/lipid ratio is used. The aim of this work was to develop SLN with high EE using a low surfactant/lipid ratio. Different formulations of RA-loaded SLN were prepared using glyceryl behenate as lipid matrix. The particle size, EE, zeta potential and differential scanning calorimetry (DSC) were investigated. High EE in SLN was obtained with addition of amines. These results indicate that the utilization of amines is an interesting approach to improve the EE of RA in SLN using a low surfactant/lipid ratio.
Gisele A Castro; Rodrigo L Oréfice; José M C Vilela; Margareth S Andrade; Lucas A M Ferreira
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of microencapsulation     Volume:  24     ISSN:  0265-2048     ISO Abbreviation:  J Microencapsul     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-20     Completed Date:  2008-01-16     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  8500513     Medline TA:  J Microencapsul     Country:  England    
Other Details:
Languages:  eng     Pagination:  395-407     Citation Subset:  IM    
Faculty of Pharmacy, Department of Pharmaceutics, Federal University Minas Gerais, Brazil.
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MeSH Terms
Acne Vulgaris / drug therapy*
Administration, Cutaneous
Amines / chemistry
Calorimetry, Differential Scanning
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Compounding / methods
Drug Delivery Systems*
Excipients / chemistry
Fatty Acids / chemistry
Keratolytic Agents / administration & dosage*
Microscopy, Polarization
Nanoparticles / chemistry*
Octanols / chemistry
Particle Size
Static Electricity
Tretinoin / administration & dosage*
Reg. No./Substance:
0/Amines; 0/Delayed-Action Preparations; 0/Excipients; 0/Fatty Acids; 0/Keratolytic Agents; 0/Octanols; 18641-57-1/glyceryl behenate; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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