Document Detail


Development of a new genetic model for absence epilepsy: spike-wave seizures in C3H/He and backcross mice.
MedLine Citation:
PMID:  15800200     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To characterize the genetic basis of spike-wave discharges (SWDs) detected by electroencephalography (EEG) in C3H/He mice, substrains of C3H mice were evaluated by EEG and sensitivity to ethosuximide. Crosses with the SWD-negative strain C57BL/6J were performed to map the underlying gene(s). C3H/He substrains exhibited a modest incidence (average of 19 SWDs per hour) of 7-8 Hz SWDs when at rest, compared with the C3HeB/Fe subline (four SWDs per hour). In the mapping backcross, however, many mice showed a very high incidence (50-220 SWDs per hour) throughout the recording period. SWDs were first detected at 3.5 weeks of age, were associated with behavioral arrest, were suppressed by ethosuximide, and were strongest in the cerebral cortex and thalamus. The major C3H determinant of SWDs, spkw1 (spike-wave 1), mapped to chromosome (Chr 9), and together with a C57BL/6J determinant on Chr 8, spkw2, accounted for more than one-half of the phenotypic variation in the backcross mice. The modest SWD incidence in C3H/He mice and the high incidence in backcrosses implies that SWD could be a confounding variable for other behaviors. Because C3H/He mice have no other brain abnormalities, they are an attractive alternative for studying idiopathic absence epilepsy.
Authors:
Wayne N Frankel; Barbara Beyer; Christina R Maxwell; Stephanie Pretel; Verity A Letts; Steven J Siegel
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  25     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-31     Completed Date:  2006-03-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3452-8     Citation Subset:  IM    
Affiliation:
The Jackson Laboratory, Bar Harbor, Maine 04609, USA. wnf@jax.org
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Anticonvulsants / therapeutic use
Brain Mapping / methods
Chromosome Mapping / methods
Disease Models, Animal*
Epilepsy, Absence / drug therapy,  genetics*,  physiopathology*
Ethosuximide / therapeutic use
Inbreeding*
Mice
Mice, Inbred C3H
Models, Genetic*
Theta Rhythm / drug effects
Grant Support
ID/Acronym/Agency:
NS31348/NS/NINDS NIH HHS; P50 MH 6404501/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Anticonvulsants; 77-67-8/Ethosuximide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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