Document Detail


Development of neuroventricular cells into ocular pigment cells in embryonic chick eyes: morphometrical and electrophysiological observations.
MedLine Citation:
PMID:  10022337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of neuro-ventricular cells into pigment cells (outer layer of the optic cup) was studied morphometrically and electrophysiologically in eye primordia of chick embryos. The prospective pigment cells are homogeneous until days 4 to 5 1/2 of embryonic development. During this period, all cells are devoid of pigment and display a basic neuroventricular profile of both inward (probably sodium) and outward (potassium) currents evoked by depolarization. Pigment cell differentiation occurs rapidly between days 5 and 6. On day 6 most cells are pigmented and respond to depolarization with outward currents only. Inward currents were elicted only in a few pigmented cells. By contrast, the minority of unpigmented cells (or cells with faintly dark cytoplasmic inclusions, probably premelanosomes) still present on day six displayed the "immature" pattern of mixed inward and outward currents. We conclude, that the differentiation of neuroepithelial cells into pigment cells involves both the synthesis of pigment granula and the down-regulation of the expression of inward current-mediating ion channels in their membrane.
Authors:
E Buse; R Jürgens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal für Hirnforschung     Volume:  39     ISSN:  0021-8359     ISO Abbreviation:  J Hirnforsch     Publication Date:  1998  
Date Detail:
Created Date:  1999-05-07     Completed Date:  1999-05-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0421521     Medline TA:  J Hirnforsch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Affiliation:
Anatomisches Institut der Universität Kiel, FRG.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Lineage
Chick Embryo
Electrophysiology
Membrane Potentials / physiology
Patch-Clamp Techniques
Phenotype
Pigment Epithelium of Eye / cytology,  embryology*,  physiology
Sodium Channels / physiology
Time Factors
Chemical
Reg. No./Substance:
0/Sodium Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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