Document Detail

Development of a neurotechnological system for relieving phantom limb pain using transverse intrafascicular electrodes (TIME).
MedLine Citation:
PMID:  23037514     Owner:  NLM     Status:  Publisher    
Abstract Phantom limb pain (PLP) is a chronic condition that develops in the majority of amputees. The underlying mechanisms are not completely understood, and thus, no treatment is fully effective. Based on recent studies, we hypothesize that electrical stimulation of afferent nerves might alleviate PLP by giving sensory input to the patient if nerve fibers can be activated selectively. The critical component in this scheme is the implantable electrode structure. We present a review of a novel electrode concept to distribute highly selective electrode contacts over the complete cross section of a peripheral nerve to create a distributed activation of small nerve fiber ensembles at the fascicular level, the transverse intrafascicular multichannel nerve electrode (TIME). The acute and chronic implantations in a small animal model exhibited a good surface and structural biocompatibility as well as excellent selectivity. Implantation studies on large animal models that are closer to human nerve size and anatomical complexity have also been conducted. They proved implant stability and the ability to selectively activate nerve fascicles in a limited proximity to the implant. These encouraging results have opened the way forward for human clinical trials in amputees to investigate the effect of selective electrical stimulation on PLP.
Thomas Stieglitz; Tim Boretius; Xavier Navarro; Jordi Badia; David Guiraud; Jean-Louis Divoux; Silvestro Micera; Paolo Maria Rossini; Ken Yoshida; Kristian R Harreby; Aritra Kundu; Winnie Jensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Biomedizinische Technik. Biomedical engineering     Volume:  0     ISSN:  1862-278X     ISO Abbreviation:  Biomed Tech (Berl)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1262533     Medline TA:  Biomed Tech (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-9     Citation Subset:  -    
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