| Development of the neural crest-derived intrinsic innervation of the human lung. | |
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MedLine Citation:
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PMID: 17884989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The formation of neural tissue, in association with airway smooth muscle (ASM), is a feature of normal lung development and function. Intrinsic neuronal tissue has recently been shown, in animal models, to be derived from neural crest cells (NCC). Since defects in NCC development underlie a range of disease states (neurocristopathies), it is important to determine the spatiotemporal development of NCC in the human lung, as defects in their development could have pathophysiologic implications. The aims of this study were to: (1) establish a time course for the formation of ASM and neural tissue within the embryonic and fetal human lung, (2) investigate whether intrinsic neural tissue within the lung is derived from NCC, and (3) gain insight into the possible signaling mechanisms underlying the development of the intrinsic lung innervation. Using human lung tissue from Weeks 6 to 12 of gestation, we analyzed the formation of ASM, NCC, neuronal and glial tissue, and the expression of Gfralpha1, a receptor component of the RET (rearranged during transfection) tyrosine kinase signaling pathway. Our results showed that NCC accumulated along the branching airways, in close association with the ASM, and differentiated into neurons and glia. Neural crest-derived neural tissue within the lung strongly expressed membrane-bound Gfralpha1, and soluble Gfralpha1 was expressed within the lung mesenchyme, but only at early developmental stages. Together these findings indicate that the intrinsic innervation of the human lung is derived from the neural crest. |
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Authors:
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Alan J Burns; Nikhil Thapar; Amanda J Barlow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-09-20 |
Journal Detail:
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Title: American journal of respiratory cell and molecular biology Volume: 38 ISSN: 1535-4989 ISO Abbreviation: Am. J. Respir. Cell Mol. Biol. Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-02-18 Completed Date: 2008-03-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8917225 Medline TA: Am J Respir Cell Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 269-75 Citation Subset: IM |
Affiliation:
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Neural Development Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. A.Burns@ich.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation Enteric Nervous System / embryology*, metabolism Female Fetal Organ Maturity Ganglia / metabolism Glial Fibrillary Acidic Protein / metabolism Humans Immunohistochemistry Lung / embryology*, innervation* Neural Crest / cytology* Neuroglia / metabolism Neurons / metabolism Pregnancy Pregnancy Trimester, First Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Glial Fibrillary Acidic Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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