Document Detail


Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage.
MedLine Citation:
PMID:  16115703     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For vaccine development it is important to know how antibodies develop after natural pneumococcal contacts. This work was done to receive information about the development of natural antibodies to pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA) and pneumolysin (Ply), in early infancy and to receive information on how nasopharyngeal carriage of Streptococcus pneumoniae in infants affects the antibody concentrations. The antibody concentrations to PspA, PsaA and Ply were measured by EIA in serum samples of 51 pregnant women, in six consecutive serum samples of 173 infants (samples from 7 to 48 weeks of age), as well as in 39 cord bloods. Nasopharyngeal swabs were also collected from the infants and cultured for pneumococci. The geometric mean concentration (GMC) of anti-PspA and -Ply decreased until 18 weeks of age and started to increase thereafter, but was still at 48 weeks lower than in the mothers. The GMC of anti-PsaA in the infants increased significantly by age and reached the GMC of the mothers already at 14 weeks of age. The increase in antibody concentration in the infants was associated with pneumococcal carriage, but followed the different kinetics depending on the antigen. High maternal anti-Ply antibodies were negatively associated with the risk of pneumococcal carriage (OR 0.78, 0.61-0.99). This indicates that high maternal anti-Ply could be associated with lower pneumococcal carriage acquisition in infants.
Authors:
Emma Holmlund; Beatriz Quiambao; Jukka Ollgren; Hanna Nohynek; Helena Käyhty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-03
Journal Detail:
Title:  Vaccine     Volume:  24     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  57-65     Citation Subset:  IM    
Affiliation:
Vaccine Immunology Laboratory, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland. emma.holmlund@ktl.fi
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MeSH Terms
Descriptor/Qualifier:
Adhesins, Bacterial / immunology*
Antibodies, Bacterial / blood*
Bacterial Proteins / immunology*
Female
Humans
Immunity, Maternally-Acquired
Infant
Infant, Newborn
Logistic Models
Nasopharynx / microbiology*
Pneumococcal Vaccines / immunology*
Pregnancy
Streptococcus pneumoniae / immunology,  isolation & purification*
Streptolysins / immunology*
Chemical
Reg. No./Substance:
0/Adhesins, Bacterial; 0/Antibodies, Bacterial; 0/Bacterial Proteins; 0/Pneumococcal Vaccines; 0/Streptolysins; 0/plY protein, Streptococcus pneumoniae; 0/pneumococcal surface protein A

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