| Development of nanoparticulate drug delivery systems based on thiolated poly(acrylic acid). | |
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MedLine Citation:
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PMID: 18946801 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this study the preparation and stabilization of poly(acrylic acid)-cysteine nanoparticles and incorporation of a fluorescence marked model-compound was investigated. Nanoparticles were prepared by ionic gelation of a poly(acrylic acid)-cysteine conjugate with calcium chloride. Poly(acrylic acid)-cysteine nanoparticles display high cohesive properties due to a cross-linking process via calcium bridges in the core and the pervasive formation of disulphide bonds and were 139 ± 34 nm in size. Nanoparticles were loaded with FITC-dextrans (flourescein isothiocyanate-dextrans) of 4, 20 and 40 kDa molecular mass as model-compound via sonication method or via vibration method for 3 and 24 h. In vitro release studies showed an initial burst release followed by an extended release of model-compounds. The lower the molecular mass of the FITC-dextrans, the higher was the amount of incorporated and released model compounds. Vibration seems to be a proper method for the incorporation of hydrophilic and macromolecular drugs in poly(acrylic acid)-cysteine nanoparticles. |
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Authors:
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Michael H Thaurer; Britta Deutel; Wolfgang Schlocker; Andreas Bernkop-Schnürch |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of microencapsulation Volume: 26 ISSN: 1464-5246 ISO Abbreviation: J Microencapsul Publication Date: 2009 May |
Date Detail:
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Created Date: 2011-02-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500513 Medline TA: J Microencapsul Country: England |
Other Details:
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Languages: eng Pagination: 187-94 Citation Subset: IM |
Affiliation:
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ThioMatrix GmbH, Research Center, Innsbruck, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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