Document Detail


Development of nanofiber-covered stents using electrospinning: in vitro and acute phase in vivo experiments.
MedLine Citation:
PMID:  18712811     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There are some technical difficulties in treating for a broad necked aneurysm and a higher incidence of recurrence. Because of these drawbacks, more innovative techniques for superior endovascular reconstructive treatment are required. We developed a novel covered stent employing electrospinning to deposit fine polyurethane (PU) fibers onto stents. An in vitro water leak test was designed and applied prior to animal testing to estimate the performance of covered stents and to determine the appropriate amount of PU fibers on a stent. Two tenths of a milligram of PU fibers proved to be sufficient to prevent water leakage. Then, the efficacy of the covered stents to that of bare stents was compared using 10 rabbits in which model aneurysms had been formed at the right common carotid artery by the elastase method. Angiographic evaluation on day 1 posttreatment (acute phase) revealed complete occlusion of the aneurysms and the patency of the parent arteries in animals treated with covered stents. At 10 days poststenting (subacute phase), the aneurysm neck was completely covered with neointimal layer as shown by scanning electron microscopic examination. The PU-covered stent holds promise as a device for treating cerebral aneurysms.
Authors:
Keita Kuraishi; Hiroo Iwata; Shigeyuki Nakano; Shinichiro Kubota; Hiroyuki Tonami; Mitsuaki Toda; Naoki Toma; Satoshi Matsushima; Kazuhide Hamada; Satoru Ogawa; Waro Taki
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part B, Applied biomaterials     Volume:  88     ISSN:  1552-4981     ISO Abbreviation:  J. Biomed. Mater. Res. Part B Appl. Biomater.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-08     Completed Date:  2009-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234238     Medline TA:  J Biomed Mater Res B Appl Biomater     Country:  United States    
Other Details:
Languages:  eng     Pagination:  230-9     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley Periodicals, Inc.
Affiliation:
Department of Neurosurgery, Mie University, Mie, Japan. kuraishikeita@yahoo.co.jp
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MeSH Terms
Descriptor/Qualifier:
Aneurysm / therapy*
Angiography / methods
Animals
Blood Vessel Prosthesis*
Carotid Arteries / pathology
Carotid Artery Diseases / pathology,  therapy*
Electrochemistry / methods
Intracranial Aneurysm / pathology*
Metals / chemistry
Microscopy, Electron, Scanning / methods
Nanostructures / chemistry*
Polyurethanes / chemistry*
Rabbits
Stents*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Metals; 0/Polyurethanes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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