Document Detail

Development of multiple sclerosis after vaccination against hepatitis B: a study based on human leucocyte antigen haplotypes.
MedLine Citation:
PMID:  16948644     Owner:  NLM     Status:  MEDLINE    
The aetiology of multiple sclerosis (MS) is still not fully understood. Infectious agents are believed to play a role in the development of this multifactorial disease. Cases in which this disease occurs after administration of both plasma-derived and recombinant hepatitis B vaccines have been reported. In this study, we compared a group of 11 MS patients who developed first clinical symptoms after hepatitis B vaccination (group I) with 71 MS patients who were never vaccinated against hepatitis B and were negative for hepatitis B serology (group II), and 20 healthy controls (group III). Mean age was 27.75 years (19-39) in group I, 30.16 years (18-50) in group II, and 34.4 years (18-50) in group III. Mean attack rate after 2 years was 1.5 in group I and 1.63 in group II. Mean Expanded Disability Status Scale score after 2 years was 1.31 in group I and 1.89 in group II. Human leucocyte antigen (HLA) typing and serology for hepatitis B surface antigen were performed in all groups. In groups I and II, HLA-DR2 was more frequent than in normal healthy subjects. This reflects the general role of HLA in the pathogenesis of MS but suggests that antigen presentation by different HLA is not involved in the development of MS after hepatitis B vaccination. Since there was no difference in the clinical features between vaccinated and nonvaccinated MS patients, this study supports recent reports that hepatitis B vaccination is safe in MS patients and that hepatitis B vaccination is not involved in the development of MS.
S Ozakbas; E Idiman; B Yulug; B Pakoz; H Bahar; Z Gulay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  68     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-04     Completed Date:  2006-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
Department of Neurology, Dokuz Eylul University Faculty of Medicine, Balcova, Izmir, Turkey.
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MeSH Terms
HLA-DR2 Antigen / immunology*
Hepatitis B / prevention & control
Hepatitis B Vaccines / adverse effects*,  immunology
Middle Aged
Multiple Sclerosis / etiology*,  immunology
Reg. No./Substance:
0/HLA-DR2 Antigen; 0/Hepatitis B Vaccines

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