| Development of a morphometric magnetic resonance image parameter suitable for distinguishing between normal dogs and dogs with cerebellar atrophy. | |
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MedLine Citation:
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PMID: 20469545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurodegenerative diseases affect the cerebellum of numerous dog breeds. Although subjective, magnetic resonance (MR) imaging has been used to detect cerebellar atrophy in these diseases, but there are few data available on the normal size range of the cerebellum relative to other brain regions. The purpose of this study was to determine whether the size of the cerebellum maintains a consistent ratio with other brain regions in different ages and breeds of normal dogs and to define a measurement that can be used to identify cerebellar atrophy on MR images. Images from 52 normal and 13 dogs with cerebellar degenerative diseases were obtained. Volume and mid-sagittal cross-sectional area of the forebrain, brainstem, and cerebellum were calculated for each normal dog and compared between different breeds and ages as absolute and relative values. The ratio of the cerebellum to total brain and of the brainstem to cerebellum mid-sagittal cross-sectional area was compared between normal and affected dogs and the sensitivity and specificity of these ratios at distinguishing normal from affected dogs was calculated. The percentage of the brain occupied by the cerebellum in diverse dog breeds between 1 and 5 years of age was not significantly different, and cerebellar size did not change with increasing age. Using a cut off of 89%, the ratio between the brainstem and cerebellum mid-sagittal cross-sectional area could be used successfully to differentiate affected from unaffected dogs with a sensitivity and specificity of 100%, making this ratio an effective tool for identifying cerebellar atrophy on MR images. |
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Authors:
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Ryan A Thames; Ian D Robertson; Thomas Flegel; Diana Henke; Dennis P O'Brien; Joan R Coates; Natasha J Olby |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association Volume: 51 ISSN: 1058-8183 ISO Abbreviation: Vet Radiol Ultrasound Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-05-17 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9209635 Medline TA: Vet Radiol Ultrasound Country: United States |
Other Details:
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Languages: eng Pagination: 246-53 Citation Subset: IM |
Affiliation:
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College of Veterinary Medicine, 4700 Hillsborough St., Raleigh, NC 27606, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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pathology Animals Atrophy Brain / pathology Cerebellar Diseases / diagnosis, veterinary* Cerebellum / pathology* Dog Diseases / diagnosis* Dogs Magnetic Resonance Imaging* Neurodegenerative Diseases / diagnosis, veterinary* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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