| Development of morphine glucuronidation in premature neonates. | |
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MedLine Citation:
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PMID: 7948434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In premature neonates (25-34 weeks gestation) who were given morphine intravenously during the first 24 h of life, only morphine, and morphine-3-glucuronide (M3G) were detected in plasma obtained after a 2-hour loading infusion, but morphine-6-glucuronide (M6G) could also be quantified following 24 h of continuous infusion. M3G/morphine and M6G/morphine plasma concentration ratios increased significantly with increasing birth weight. However, the M6G/M3G plasma concentration ratio decreased with increasing birth weight (and gestational age), thus providing the first indication in vivo of the differential development of uridinediphosphate glucuronosyltransferases in humans. |
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Authors:
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R Hartley; M Green; M W Quinn; J A Rushforth; M I Levene |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biology of the neonate Volume: 66 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1994 |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Department of Clinical Medicine, University of Leeds, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Birth Weight Female Gestational Age Humans Infant, Newborn Infant, Premature / blood* Kinetics Male Morphine / administration & dosage, blood*, therapeutic use Morphine Derivatives / blood* |
| Chemical | |
Reg. No./Substance:
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0/Morphine Derivatives; 20290-09-9/morphine-3-glucuronide; 20290-10-2/morphine-6-glucuronide; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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