Document Detail

Development of morphine glucuronidation in premature neonates.
MedLine Citation:
PMID:  7948434     Owner:  NLM     Status:  MEDLINE    
In premature neonates (25-34 weeks gestation) who were given morphine intravenously during the first 24 h of life, only morphine, and morphine-3-glucuronide (M3G) were detected in plasma obtained after a 2-hour loading infusion, but morphine-6-glucuronide (M6G) could also be quantified following 24 h of continuous infusion. M3G/morphine and M6G/morphine plasma concentration ratios increased significantly with increasing birth weight. However, the M6G/M3G plasma concentration ratio decreased with increasing birth weight (and gestational age), thus providing the first indication in vivo of the differential development of uridinediphosphate glucuronosyltransferases in humans.
R Hartley; M Green; M W Quinn; J A Rushforth; M I Levene
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  66     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-9     Citation Subset:  IM    
Department of Clinical Medicine, University of Leeds, UK.
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MeSH Terms
Birth Weight
Gestational Age
Infant, Newborn
Infant, Premature / blood*
Morphine / administration & dosage,  blood*,  therapeutic use
Morphine Derivatives / blood*
Reg. No./Substance:
0/Morphine Derivatives; 20290-09-9/morphine-3-glucuronide; 20290-10-2/morphine-6-glucuronide; 57-27-2/Morphine

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