| Development of a miniaturized heart-lung machine for neonates with congenital heart defect. | |
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MedLine Citation:
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PMID: 18812743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Predominantly, standard adult heart lung machines are used for pediatric cardiac surgery, only with individually downsized components. Downsizing is limited, e.g., by the required gas exchange surface. To diminish complications, we developed a new miniaturized heart lung machine (MiniHLM) for neonates, with significantly reduced priming volume and blood contact surface by integration of all major system components in one single device. In particular, a rotary blood pump is centrically integrated into the oxygenator and the cardiotomy reservoir with integrated heat exchanger is directly connected. Thus, tubing is only necessary between patient and MiniHLM. A total priming volume of 102 ml could be achieved for the entire extracorporeal circuit (including arterial/venous line), in contrast to the currently smallest device on the market with 213 ml. In first animal experiments with female New Zealand rabbits, the MiniHLM guaranteed both a sufficient gas exchange and an adequate blood flow; 12 rabbits could successfully be weaned off after 1 hour of aortic clamp time. The first in vitro and in vivo tests confirm the concept of the MiniHLM. Its low priming volume and blood contact surface may significantly reduce complications during heart surgery in neonates. |
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Authors:
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Jutta Arens; Heike Schnöring; Fabian Reisch; Jaime F Vázquez-Jiménez; Thomas Schmitz-Rode; Ulrich Steinseifer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 54 ISSN: 1538-943X ISO Abbreviation: ASAIO J. Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2008-09-24 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: United States |
Other Details:
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Languages: eng Pagination: 509-13 Citation Subset: IM |
Affiliation:
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Applied Medical Engineering, Helmholtz Institute Aachen, Aachen, Germany. arens@hia.rwth-aachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Equipment Design Female Heart Defects, Congenital / surgery* Heart-Lung Machine* Humans Infant, Newborn Miniaturization / instrumentation Oxygenators, Membrane Pulmonary Gas Exchange Rabbits |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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