| Development of microscopic polyangiitis in patients with chronic airway disease. | |
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MedLine Citation:
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PMID: 16211463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microscopic polyangiitis (MPA) is a rare systemic vasculitis syndrome, which is often accompanied by positive myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA). While pulmonary involvement of MPA consists mainly of diffuse alveolar hemorrhage and interstitial pneumonia, bronchiectasis has been reported as a pulmonary lesion in association with MPA. To investigate the clinical features of patients with MPA, focusing on the presence or the absence of preceding chronic airway diseases (CAD), we conducted a retrospective observational study of 26 patients in the last 13 years at Saga University Hospital. The clinical records and radiologic chest examinations were reviewed retrospectively. Pulmonary manifestations were alveolar hemorrhage in 3 patients (12%) and interstitial pneumonia in 5 (19%). Bronchiectasis, defined by the findings of chest radiograph and computed tomography, was found in 9 patients (35%). Four patients (15%) with bronchiectasis and one patient (4%) with chronic bronchitis had experienced chronic bronchial suppuration prior to the onset of MPA. Ten patients were classified as having chronic airway disease (CAD) before the onset of MPA. MPO-ANCA tended to be lower in the CAD group than in the non-CAD group. None of the patients in the CAD group had pulmonary hemorrhage or interstitial pneumonia. Only one patient (10%) in the CAD group died within 90 days of the onset of MPA, while 7 (43.8%) of the non-CAD group died. Our study suggests that MPA may result in part from CAD and that the clinical course of MPA with CAD may be different from MPA without CAD. |
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Authors:
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K Takahashi; S Hayashi; O Ushiyama; N Sueoka; M Fukuoka; K Nagasawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lung Volume: 183 ISSN: 0341-2040 ISO Abbreviation: Lung Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-10-07 Completed Date: 2005-11-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
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Languages: eng Pagination: 273-81 Citation Subset: IM |
Affiliation:
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Department of Medicine, Saga University Medical School, Nabeshima 5-1-1, Saga 849-8501, Japan. hayashs@cc.saga-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Antibodies, Antineutrophil Cytoplasmic / immunology Chronic Disease Female Humans Lung Diseases / complications*, mortality Male Middle Aged Peroxidase / immunology Retrospective Studies Vasculitis / etiology* |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Antineutrophil Cytoplasmic; EC 1.11.1.7/Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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