Document Detail


Development of a microsatellite genetic map spanning 5q31-q33 and subsequent placement of the LGMD1A locus between D5S178 and IL9.
MedLine Citation:
PMID:  7881291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of disorders. We previously localized an autosomal dominant form of the disorder (LGMD1A) to chromosome 5q22-31 by linkage analysis in a single large pedigree. After developing a microsatellite genetic map incorporating six loci in q31-33 of chromosome 5 and spanning 35 cM, we have refined the original localization. Using multipoint analysis, LGMD1A is localised to a 7 cM region between the markers IL9 and D5S178 with odds > 1000:1.
Authors:
L H Yamaoka; C A Westbrook; M C Speer; J M Gilchrist; E W Jabs; E G Schweins; J M Stajich; P C Gaskell; A D Roses; M A Pericak-Vance
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuromuscular disorders : NMD     Volume:  4     ISSN:  0960-8966     ISO Abbreviation:  Neuromuscul. Disord.     Publication Date:    1994 Sep-Nov
Date Detail:
Created Date:  1995-04-11     Completed Date:  1995-04-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9111470     Medline TA:  Neuromuscul Disord     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  471-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Descriptor/Qualifier:
Chromosome Mapping*
DNA, Satellite / analysis*
Genotype
Haplotypes
Humans
Linkage (Genetics)
Lod Score
Muscular Dystrophies / genetics*
Polymorphism, Genetic
Grant Support
ID/Acronym/Agency:
CA40046/CA/NCI NIH HHS; MO1-RR30/RR/NCRR NIH HHS; NS26330/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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