| Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization. | |
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MedLine Citation:
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PMID: 19005594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N-Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl carrier proteins. To fully explore the chemical diversity and inhibitory potential of these analogues we have developed a simple method for the parallel synthesis and purification of any number of pantothenamides from a single precursor, and subsequently evaluated a small library of these compounds as inhibitors of bacterial growth to demonstrate the potential and utility of the method. |
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Authors:
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Marianne van Wyk; Erick Strauss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-17 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 6 ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-13 Completed Date: 2008-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 4348-55 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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chemistry Cell Proliferation / drug effects Coenzyme A / antagonists & inhibitors*, biosynthesis, metabolism* Enzyme Inhibitors / chemical synthesis*, chemistry, isolation & purification*, pharmacology Escherichia coli / cytology, drug effects Kinetin Nitrogen / chemistry* Pantothenic Acid / analogs & derivatives, chemical synthesis*, isolation & purification*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Enzyme Inhibitors; 525-79-1/Kinetin; 7727-37-9/Nitrogen; 79-83-4/Pantothenic Acid; 85-61-0/Coenzyme A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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