Document Detail

Development of a method for the parallel synthesis and purification of N-substituted pantothenamides, known inhibitors of coenzyme A biosynthesis and utilization.
MedLine Citation:
PMID:  19005594     Owner:  NLM     Status:  MEDLINE    
N-Substituted pantothenamides are a class of pantothenic acid analogues which have been shown to act as inhibitors of coenzyme A biosynthesis and utilization, especially by blocking fatty acid metabolism through formation of inactive acyl carrier proteins. To fully explore the chemical diversity and inhibitory potential of these analogues we have developed a simple method for the parallel synthesis and purification of any number of pantothenamides from a single precursor, and subsequently evaluated a small library of these compounds as inhibitors of bacterial growth to demonstrate the potential and utility of the method.
Marianne van Wyk; Erick Strauss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-17
Journal Detail:
Title:  Organic & biomolecular chemistry     Volume:  6     ISSN:  1477-0539     ISO Abbreviation:  Org. Biomol. Chem.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-13     Completed Date:  2008-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101154995     Medline TA:  Org Biomol Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  4348-55     Citation Subset:  IM    
Department of Biochemistry, Stellenbosch University, Matieland 7602, South Africa.
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MeSH Terms
Amines / chemistry
Cell Proliferation / drug effects
Coenzyme A / antagonists & inhibitors*,  biosynthesis,  metabolism*
Enzyme Inhibitors / chemical synthesis*,  chemistry,  isolation & purification*,  pharmacology
Escherichia coli / cytology,  drug effects
Nitrogen / chemistry*
Pantothenic Acid / analogs & derivatives,  chemical synthesis*,  isolation & purification*,  pharmacology
Reg. No./Substance:
0/Amines; 0/Enzyme Inhibitors; 525-79-1/Kinetin; 7727-37-9/Nitrogen; 79-83-4/Pantothenic Acid; 85-61-0/Coenzyme A

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