Document Detail

Development of meloxicam-loaded electrospun polyvinyl alcohol mats as a transdermal therapeutic agent.
MedLine Citation:
PMID:  18800295     Owner:  NLM     Status:  MEDLINE    
This study reports on the use of electrospun polyvinyl alcohol (PVA) nanofiber mats loaded with meloxicam (MX) as a transdermal drug delivery system. The amounts of MX loaded in the base PVA solution (10% w/v solution) were 2.5, 5, 10 and 20% weight, based on the dry weight of PVA (% wt). The average diameters of these fibers ranged from 121-185 nm. In all concentrations of MX loaded in spun PVA fiber mats, an amorphous nanodispersion of MX with PVA was obtained. Both the degree of swelling and the weight loss of the electrospun PVA mats were greater than those of the as-cast PVA films. The tensile strength of the as-spun fiber mats was lower than that of the as-cast PVA films, but the strain at the maximum of the as-spun fiber mats was about six times higher than that of the as-cast PVA films. The skin permeation flux of the MX permeated from MX-loaded as-spun PVA were significantly higher than from MX-loaded as-cast PVA films, and increased when the MX content in both MX-loaded as-spun PVA and MX-loaded as-cast PVA films was increased. Our research suggests a potential use for MX-loaded electrospun PVA mats as a transdermal drug delivery system.
Tanasait Ngawhirunpat; Praneet Opanasopit; Theerasak Rojanarata; Prasert Akkaramongkolporn; Uracha Ruktanonchai; Pitt Supaphol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  14     ISSN:  1097-9867     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2009  
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-9     Citation Subset:  IM    
Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
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MeSH Terms
Administration, Cutaneous
Anti-Inflammatory Agents, Non-Steroidal / chemistry*,  therapeutic use*
Dose-Response Relationship, Drug
Electric Conductivity
Electrochemical Techniques / methods*
Molecular Structure
Polyvinyl Alcohol / chemistry*
Skin / drug effects,  metabolism
Solutions / chemistry
Technology, Pharmaceutical / methods*
Tensile Strength
Thiazines / chemistry*,  therapeutic use*
Thiazoles / chemistry*,  therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Solutions; 0/Thiazines; 0/Thiazoles; 71125-38-7/meloxicam; 9002-89-5/Polyvinyl Alcohol

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