Document Detail

Development of a mathematical model for the prediction of the area of venous leak.
MedLine Citation:
PMID:  11494081     Owner:  NLM     Status:  MEDLINE    
Erectile dysfunction (ED) is an increasingly prevalent medical problem, affecting up to 50% of men aged between 40 and 70-y-old. Many cases are vasculogenic and some of these stem from the inability of the penis to store blood during erection due to leak into the venous system, termed corporo-venocclusive dysfunction (CVOD). The area of leakage during erection could be the most direct measure of erectile function but has not been investigated before. We have developed a simple mathematical model to determine the area of leak during erection and have tested it on data from both normal men (n=3) and men with venogenic impotence (n=16) undergoing dynamic infusion cavernosometry (DIC). The area of leak in the impotent group is significantly greater than in normal men at intracorporal pressures above 30 mmHg and reaches a plateau between 60 and 90 mmHg. Based on this study, we suggest that it may be necessary only to perform DIC at intracorporal pressures between 60 and 90 mmHg.
J P Mulhall; M S Damaser
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of impotence research     Volume:  13     ISSN:  0955-9930     ISO Abbreviation:  Int. J. Impot. Res.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-08     Completed Date:  2001-10-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007383     Medline TA:  Int J Impot Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  236-9     Citation Subset:  IM    
Department of Urology, Loyola University Medical Center and Research Service, Hines Veterans Administration Hospital, Maywood, IL 60153, USA.
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MeSH Terms
Capillary Permeability*
Erectile Dysfunction / diagnosis,  etiology
Models, Cardiovascular*
Penis / blood supply*
Regional Blood Flow
Urology / methods
Vascular Diseases / complications
Veins / metabolism

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