| Development of manganese-based nanoparticles as contrast probes for magnetic resonance imaging. | |
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MedLine Citation:
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PMID: 22272218 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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MRI is one of the most important imaging tools in clinics. It interrogates nuclei of atoms in a living subject, providing detailed delineation with high spatial and temporal resolutions. To compensate the innate low sensitivity, MRI contrast probes were developed and widely used. These are typically paramagnetic or superparamagnetic materials, functioning by reducing relaxation times of nearby protons. Previously, gadolinium(Gd)-based T(1) contrast probes were dominantly used. However, it was found recently that their uses are occasionally associated with nephrogenic system fibrosis (NSF), which suggests a need of finding alternatives. Among the efforts, manganese-containing nanoparticles have attracted much attention. By careful engineering, manganese nanoparticles with comparable r(1) relaxivities can be yielded. Moreover, other functionalities, be a targeting motif, a therapeutic agent or a second imaging component, can be loaded onto these nanoparticles, resulting in multifunctional nanoplatforms. |
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Authors:
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Zipeng Zhen; Jin Xie |
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Publication Detail:
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Type: Journal Article Date: 2012-01-01 |
Journal Detail:
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Title: Theranostics Volume: 2 ISSN: 1838-7640 ISO Abbreviation: Theranostics Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101552395 Medline TA: Theranostics Country: Australia |
Other Details:
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Languages: eng Pagination: 45-54 Citation Subset: - |
Affiliation:
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Department of Chemistry and Bio-Imaging Research Center (BIRC), University of Georgia, Athens, GA 30602. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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