| Development of a low flow resistance intravenous oxygenator. | |
| | |
MedLine Citation:
|
PMID: 9360141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A potentially attractive support device for patients with acute respiratory failure is an intravenous membrane oxygenator. One problem, however, is that the membrane surface area required for sufficient gas exchange can unduly increase vena caval pressure drop and impede venous return. The purpose of this study was to design and develop an intravenous oxygenator that would offer minimal venous flow resistance in situ. The device uses a constrained fiber bundle of smaller cross sectional size than the vena cava so as to effect an intentional shunt flow of venous blood around the fiber bundle and reduce the venous pressure drop caused by the device. A pulsating balloon within the fiber bundle redirects part of this shunt flow into reciprocating flow in and out of the fiber bundle. This offers dual advantages: 1) Blood flow through the fiber bundle is mainly perpendicular to the fibers; and 2) the requisite energy for driving flow comes largely from the pneumatic system pulsating the balloon, not from a venous pressure drop. In this mode a full length device with a 2 cm fiber bundle in a 2.5 cm blood vessel would offer a pressure drop of only a few millimeters of mercury. The use of constrained fiber bundles requires good uniformity of fiber spacing for effective gas exchange. Several prototypes have been fabricated, and CO2 and O2 exchange rates of up to 402 and 347 ml/min/m2 have been achieved during acute animal implantation. |
| | |
Authors:
|
W J Federspiel; M S Hout; T J Hewitt; L W Lund; S A Heinrich; P Litwak; F R Walters; G D Reeder; H S Borovetz; B G Hattler |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: ASAIO journal (American Society for Artificial Internal Organs : 1992) Volume: 43 ISSN: 1058-2916 ISO Abbreviation: ASAIO J. Publication Date: 1997 Sep-Oct |
Date Detail:
|
Created Date: 1998-01-15 Completed Date: 1998-01-15 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9204109 Medline TA: ASAIO J Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: M725-30 Citation Subset: IM |
Affiliation:
|
McGowan Center for Artificial Organ Development, Department of Surgery, University of Pittsburgh, PA 15219, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biomedical Engineering Blood Pressure Carbon Monoxide / blood Cattle Equipment Design Evaluation Studies as Topic Humans Oxygen / blood Oxygenators, Membrane* Respiratory Distress Syndrome, Adult / blood, physiopathology, therapy |
| Chemical | |
Reg. No./Substance:
|
630-08-0/Carbon Monoxide; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An improved blood substitute. In vivo evaluation of its renal effects.
Next Document: A new double lumen balloon catheter for retrograde cerebral perfusion via jugular vein cannulation.