Document Detail


Development of a light-scattering immunoassay for thyroxine-binding prealbumin in plasma or serum.
MedLine Citation:
PMID:  18963769     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This paper describes the development of an assay for the measurement of thyroxine binding prealbumin in plasma or serum, based on the technique of fixed-time kinetic immunoturbidimetry with the Cobas Bio centrifugal analyser. The assay has good precision (coefficient of variation < 5%) and a detection limit of 15 mg l . The assay is rapid, economical, and the results compare well with those obtained by an established procedure. The technique has wide applicability to instruments which can make kinetic measurements and could prove useful in the clinical monitoring of patients receiving nutritional support and in the identification of nutritionally-at-risk groups prior to surgery. The assay further emphasises the sensitivity and usefulness of kinetic immunoturbidimetry for the measurement of low concentrations of proteins.
Authors:
K Spencer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Talanta     Volume:  31     ISSN:  0039-9140     ISO Abbreviation:  Talanta     Publication Date:  1984 Oct 
Date Detail:
Created Date:  2008-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  923-7     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Oldchurch Hospital, Romford, Essex, England.
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