Document Detail

Development of leptin antagonists and their potential use in experimental biology and medicine.
MedLine Citation:
PMID:  17010639     Owner:  NLM     Status:  MEDLINE    
Leptin is a pleotropic hormone that acts both centrally and peripherally. Whereas leptin exhibits positive effects on several physiological functions, such as regulation of energy metabolism, reproductive function and immune responses, negative actions, such as enhancement of undesired immune responses in autoimmune diseases, tumorigenesis, elevated blood pressure and cardiovascular pathologies, have also been documented. The recent development of leptin muteins with antagonistic properties and other proteins that block leptin activity opens up new possibilities for their use in research and, eventually, therapy.
Arieh Gertler
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-09-28
Journal Detail:
Title:  Trends in endocrinology and metabolism: TEM     Volume:  17     ISSN:  1043-2760     ISO Abbreviation:  Trends Endocrinol. Metab.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9001516     Medline TA:  Trends Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-8     Citation Subset:  IM    
The Institute of Biochemistry, Food Science, and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.
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MeSH Terms
Amino Acid Sequence
Drug Design*
Leptin / antagonists & inhibitors*,  immunology
Models, Biological
Molecular Sequence Data
Mutant Proteins / pharmacology,  physiology
Receptors, Cell Surface / immunology,  physiology
Receptors, Leptin
Sequence Homology, Amino Acid
Reg. No./Substance:
0/Leptin; 0/Mutant Proteins; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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