Document Detail

Development of isolated ACTH deficiency in a man with type I diabetes mellitus.
MedLine Citation:
PMID:  2846679     Owner:  NLM     Status:  MEDLINE    
A 45-year-old man with type I diabetes mellitus of 25-yr duration and well controlled by conventional insulin therapy developed an isolated adrenocorticotropic hormone (ACTH) deficiency. He presented with a 3-month history of weight loss, weakness, anorexia and persistent tendency to hypoglycemia that he had never experienced before. Basal and dynamic endocrine testing disclosed absent cortisol secretion caused by an isolated ACTH deficiency due to a primary pituitary defect. Corticosteroid replacement therapy allowed again a good glycometabolic control. The possible causes of hypoglycemia in insulin-treated diabetes and the pathogenetic basis of the reported association are discussed.
A Giustina; R Candrina; A Cimino; G Romanelli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  11     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  375-7     Citation Subset:  IM    
Cattedra di Patologia Speciale Medica, Università di Brescia, Italy.
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MeSH Terms
Adrenocorticotropic Hormone / deficiency*
Diabetes Mellitus, Type 1 / complications*
Hypoglycemia / etiology
Middle Aged
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone

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