| Development of intimal thickening in superficial temporal arteries in patients with moyamoya disease. | |
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MedLine Citation:
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PMID: 9409440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the possible mechanism of neointimal formation in Moyamoya disease, we histologically examined the superficial temporal arteries and also investigated cultured smooth muscle cells (SMCs) from the arteries. Intimal thickening of the scalp arteries developed significantly at an early age in Moyamoya patients compared with control subjects. The histopathological findings of the neointima in scalp arteries were almost similar to those in intracranial arteries in Moyamoya patients. SMCs cultured from Moyamoya arteries responded significantly less to serum mitogens, especially to platelet derived growth factor (PDGF), than those of control patients, the finding of which was explained by the reduced number of PDGF receptor on Moyamoya SMCs. Our findings indicate the presence of systemic factors that promote migration and proliferation of SMCs from the media to the intima in Moyamoya disease. Our results suggest that alteration in vascular cells may contribute to the development of intimal thickening in Moyamoya disease. |
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Authors:
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M Aoyagi; N Fukai; M Yamamoto; Y Matsushima; K Yamamoto |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical neurology and neurosurgery Volume: 99 Suppl 2 ISSN: 0303-8467 ISO Abbreviation: Clin Neurol Neurosurg Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1998-02-18 Completed Date: 1998-02-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7502039 Medline TA: Clin Neurol Neurosurg Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: S213-7 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Tokyo Medical and Dental University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cell Culture Techniques Cell Movement Child Child, Preschool Female Humans Male Middle Aged Moyamoya Disease / pathology* Muscle, Smooth / pathology Receptors, Platelet-Derived Growth Factor / metabolism Temporal Arteries / pathology* Tunica Intima / pathology* |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Receptors, Platelet-Derived Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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