| Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent. | |
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MedLine Citation:
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PMID: 11739877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uptake of colostrum just after birth is essential to stimulate intestinal growth and function, and in many species, including pigs, colostrum also provides immunological protection via the absorption of immunoglobulin G (IgG). In this study, intestinal growth, IgG absorptive capacity and enzyme activities were investigated in newborn pigs in response to different diets. Newborn piglets were bottle-fed porcine colostrum (PC), bovine colostrum (BC), porcine plasma (PP), porcine milk (PM), bovine colostrum containing porcine plasma (BCP) or a milk replacer (MR) every 3 h (15 mL/kg) for up to 2 d. Bovine serum albumin (BSA) was added to the diets as a macromolecule marker. The percentage of absorbed BSA just after birth was highest for piglets fed the PC diet (30-50%), lower for those fed the BC and BCP diets (23-30%) and lowest for the PP, PM and MR diet-fed piglets (7-20%, P < 0.05 relative to those fed colostrum). Porcine IgG was absorbed more efficiently than bovine IgG. Intestinal closure occurred earlier in MR and BCP piglets (within 12 h after birth) than in PC pigs. At 2 d of age, intestinal mucosal weight (+120% increase from birth) and villus morphology were similar in the PC, BCP and MR groups. All 3 groups also had increased aminopeptidase A activity compared with values at birth (+100% increase). Compared with PC pigs, the BCP group had higher sucrase and maltase activities (+50% and +200%, respectively) and lower aminopeptidase N activity (-50%, P < 0.05). Similarly, MR pigs showed elevated sucrase activity (+40%) and lowered maltase, lactase and aminopeptidase N activities (-20% to -50%, P < 0.05) compared with PC pigs. We conclude that porcine and bovine colostrum contain factors that stimulate the intestinal endocytotic and enzymatic capacity in newborn pigs. A milk replacer can produce normal gut growth, but may be inefficient in mediating normal macromolecule transport and disaccharidase activity. Bovine colostrum mixed with porcine plasma proteins may be a useful substitute for porcine colostrum in artificial rearing of newborn pigs. |
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Authors:
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A R Jensen; J Elnif; D G Burrin; P T Sangild |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 131 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-12 Completed Date: 2002-01-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 3259-65 Citation Subset: IM |
Affiliation:
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Department of Animal Science and Animal Health, Division of Animal Nutrition, Royal Veterinary and Agricultural University, DK-1870 Frederiksberg, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminopeptidases
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metabolism Animals Animals, Newborn / immunology* Antigens, CD13 / metabolism Cattle Colostrum Diet* Female Glutamyl Aminopeptidase Humans Immunoglobulin A / administration & dosage, metabolism* Intestinal Absorption Intestinal Mucosa / growth & development Intestines / anatomy & histology, enzymology*, growth & development* Organ Size Serum Albumin / pharmacokinetics Serum Albumin, Bovine / pharmacokinetics Sucrase / metabolism Swine / growth & development, immunology* alpha-Glucosidases / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Serum Albumin; 0/Serum Albumin, Bovine; EC 3.2.1.20/alpha-Glucosidases; EC 3.2.1.48/Sucrase; EC 3.4.11.-/Aminopeptidases; EC 3.4.11.2/Antigens, CD13; EC 3.4.11.7/Glutamyl Aminopeptidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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