Document Detail

Development of integrins in the vasculature of germinal matrix, cerebral cortex, and white matter of fetuses and premature infants.
MedLine Citation:
PMID:  19960540     Owner:  NLM     Status:  MEDLINE    
Germinal matrix (GM) vasculature is selectively vulnerable to hemorrhage in premature infants during the first 48 hr of life. This is attributed to rapid angiogenesis of this brain region, resulting in formation of nascent vessels that show a paucity of pericytes and immaturity of extracellular matrix. Integrins are key regulators of angiogenesis and contribute to stabilization of cerebral vasculature by providing endothelial- and astrocyte-matrix adhesion. Therefore, we asked whether GM exhibited a distinct regional pattern of integrin expression that was dissimilar from that of the cerebral cortex and white matter in human fetuses and premature infants. To this end, we measured protein and gene expression of integrins in the GM, cortex, and white matter of human fetuses (15-22 weeks), premature infants (23-35 weeks), and mature infants (36-40 weeks). We found that protein levels of alpha5beta1 integrin were greater in the GM than in the cortex or white matter by 1.6-fold for both fetuses and premature infants. alpha5beta1 integrin mRNA expression was higher in the GM than in the cortex or white matter by 2-fold for fetuses but not for premature infants. alphaVbeta3, alphaVbeta5, alphaVbeta8, and alpha4beta1 integrin expression were comparable among GM, cortex, and white matter in fetuses and premature infants. Because alpha5beta1 integrin is a central regulator of angiogenesis, its elevation in the GM of fetuses and premature infants indicates that this might be a key activator of endothelial proliferation in this brain region. We speculate that selective alpha5beta1 integrin inhibition might suppress angiogenesis in the GM and thus prevent brain hemorrhage in premature infants.
Krishna Dummula; Govindaiah Vinukonda; Hongmin Xu; Furong Hu; Muhammad T Zia; Alex Braun; Qiuhu Shi; John Wolk; Praveen Ballabh
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience research     Volume:  88     ISSN:  1097-4547     ISO Abbreviation:  J. Neurosci. Res.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-06-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600111     Medline TA:  J Neurosci Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1193-204     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Department of Pediatrics, New York Medical College-Westchester Medical Center, Valhalla, New York, USA.
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MeSH Terms
Blood Vessels / embryology,  metabolism*
Brain / blood supply*,  embryology,  metabolism*
Cerebral Cortex / blood supply,  embryology,  metabolism*
Infant, Newborn
Infant, Premature
Integrin alpha4 / metabolism
Integrin alpha5 / metabolism
Integrin alpha5beta1 / metabolism
Integrins / metabolism*
Nerve Fibers, Myelinated / metabolism*
RNA, Messenger / metabolism
Grant Support
Reg. No./Substance:
0/Integrin alpha5; 0/Integrin alpha5beta1; 0/Integrins; 0/RNA, Messenger; 143198-26-9/Integrin alpha4

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