| Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation. | |
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MedLine Citation:
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PMID: 22175235 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aim: To monitor cells in vivo or to detect the sentinel lymph node, we developed a PET/MRI silica nanoprobe with an enhanced near-infrared fluorescence signal. Methods: We developed enhanced near-infrared fluorescent (NIRF) magnetic silica nanoparticles, MNP-SiO(2)(NIR797), that encapsulate NIRF dye in the silica. We applied this probe to visualizing cells in the deep tissue of mice using NIRF imaging. After labeling with a radioisotope, (68)Ga, on the surface of MNP-SiO(2)(NIR797), we injected it into the forepaw of mice to visualize the sentinel lymph node. Results: This encapsulated nanoprobe showed enhancement of fluorescent intensity and stability compared with the nanoprobe, which had the same dyes on the surface of the silica nanoparticles. We also obtained multimodal in vivo imaging of (68)Ga-{MNP-SiO(2)(NIR797)} applied to sentinel lymph node detection of mice using PET/MRI/NIRF images. Conclusion: This multimodal nanoprobe with enhanced fluorescence may provide a useful tool for imaging diagnostics and cell tracking. |
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Authors:
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Jun Sung Kim; Young-Hwa Kim; Jin Hyun Kim; Keon Wook Kang; Eunju Lee Tae; Hyewon Youn; Daehong Kim; Seok-Ki Kim; Jung-Taek Kwon; Myung-Haing Cho; Yun-Sang Lee; Jae Min Jeong; June-Key Chung; Dong Soo Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
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Title: Nanomedicine (London, England) Volume: - ISSN: 1748-6963 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278111 Medline TA: Nanomedicine (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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R&D Center, Biterials Co., Ltd., Seoul. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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