Document Detail

Development of an in vitro model for premature neonatal skin: biophysical characterization using transepidermal water loss.
MedLine Citation:
PMID:  15459948     Owner:  NLM     Status:  MEDLINE    
The objective was to develop an in vitro model for the developing skin of the premature neonate. Barriers of different levels of efficiency were produced by differentially tape-stripping the stratum corneum (SC) from the skin of excised porcine ears, and were characterized by measurements of transepidermal water loss (TEWL). In this way, it was possible to express the recorded TEWL as a function of percentage SC thickness (F) generating the following relationship: TEWL = 2.7 + 41.exp [- 0.028.F]. These data were then compared to previously published in vivo measurements of TEWL obtained from a population of premature neonates at various post-conceptional ages (PCA). The latter conformed to a remarkably parallel relationship to that found in vitro with the porcine skin model, namely TEWL = 3.3 + 41.exp [-0.026.(PCA-160)]. It can be suggested, therefore, that the empirically adjusted PCA (i.e., PCA-160) correlates closely with the developing thickness of the neonate's SC. The corollary is that porcine skin, in vitro, tape-stripped to a particular level, can provide a barrier corresponding to a specific degree of neonate maturation and can serve, hence, as a useful tool with which to explore whether transdermal drug delivery in this unique patient population may be beneficial.
N Sekkat; Y N Kalia; R H Guy
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  93     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-03     Completed Date:  2005-04-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2936-40     Citation Subset:  IM    
Copyright Information:
(c) 2004 Wiley-Liss, Inc. and the American Pharmacists Association
Section de Pharmacie, Faculté des Sciences, Université de Genève, 30, quai E. Ansermet, CH-1211 Genève 4, Switzerland.
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MeSH Terms
Biophysical Phenomena
Body Water / physiology
Infant, Newborn
Infant, Premature / physiology*
Models, Biological*
Skin Absorption / physiology*
Water Loss, Insensible / physiology*

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