Document Detail


Development and in vitro evaluation of thiolated chitosan-Poly(methacrylic acid) nanoparticles as a local mucoadhesive delivery system.
MedLine Citation:
PMID:  21215774     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The main objective of this study was to develop a local, oral mucoadhesive metronidazole benzoate (MET) delivery system that can be applied and removed by the patient for the treatment of periodontal diseases. The results of present study revealed that the retention time of MET at its absorption site could be increased by formulating it into nanoparticles using thiolated chitosan (TCS)-poly(methacrylic acid) (PMAA). The nanoparticles of MET prepared from TCS-PMAA may represent a useful approach for targeting its release at its site of absorption, sustaining its release and improving its oral availability.
Authors:
Mohammad Reza Saboktakin; Roya M Tabatabaie; Abel Maharramov; Mohammad Ali Ramazanov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-6
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  -     ISSN:  1879-0003     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Nanostructured Materials Synthesis Lab, International Research Institute of Arian Chemie Gostar, Tabriz, Iran; Nanotechnology Research Center, Baku State University, Baku, Azerbaijan.
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