Document Detail

Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula.
MedLine Citation:
PMID:  8543750     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Development of humoral and cellular immune responses to orally administered antigens in human beings is poorly understood, although antigen administration has been suggested as a treatment for hypersensitivity disorders and autoimmune diseases. OBJECTIVE: The purpose of the study was to investigate the development of systemic immune response in infants fed with formula containing whole cow's milk proteins or hydrolyzed formula containing casein peptides. METHODS: In a double-blind trial, 10 infants received cow's milk-based formula, and 10 infants received a casein hydrolysate formula until the age of 9 months. Blood samples were taken at the ages of 6, 9, and 12 months. Cellular responses were assessed by proliferation assay of peripheral blood mononuclear cells to cow's milk proteins (beta-lactoglobulin, bovine serum albumin, and alpha-casein). Humoral responses to the same proteins were measured by ELISA for IgG antibodies. RESULTS: Feeding infants with cow's milk-based formula induced systemic humoral and cellular responses to cow's milk proteins. T-cell response later declined, supporting the concept of oral tolerization. Exposure to cow's milk proteins after the age of 9 months resulted in depressed cellular and humoral responsiveness to these proteins. CONCLUSION: Our results support the view that induction of oral tolerance in human beings is an age-dependent phenomenon.
O Vaarala; T Saukkonen; E Savilahti; T Klemola; H K Akerblom
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  96     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  917-23     Citation Subset:  AIM; IM    
Children's Hospital, Department of Pediatrics, University of Helsinki, Finland.
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MeSH Terms
Antibody Formation / drug effects
Caseins / immunology
Double-Blind Method
Immune Tolerance / drug effects
Immunity, Cellular / drug effects
Infant Food / adverse effects*
Infant, Newborn
Milk Hypersensitivity / immunology
Milk Proteins / immunology*
Pilot Projects
Protein Hydrolysates / immunology
Reg. No./Substance:
0/Caseins; 0/Milk Proteins; 0/Protein Hydrolysates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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