Document Detail

Development of hypothalamic-pituitary-adrenal response to stress in rats made hypothyroid by exposure to thiouracil from conception.
MedLine Citation:
PMID:  7276798     Owner:  NLM     Status:  MEDLINE    
The functional maturation of the hypothalamic-pituitary-adrenal (HPA) axis has been studied in rats of 20-35 days of age made hypothyroid by the administration of thiouracil from conception. Basal concentrations of corticosterone in serum were normal in hypothyroid animals. Ether stress led to an increase corticosterone content of the adrenal glands of hypothyroid and normal rats but not to a rise in serum corticosterone of hypothyroid rats until 30 days of age. Corticosterone secretion in response to ACTH administration was subnormal in hypothyroid rats. The hypothyroid state delays the development of the hypothalamic-pituitary-portion of the HPA axis until 30 days of age and causes a diminution in adrenal response to ACTH beyond this time.
L A Meserve; J H Leathem
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  90     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  1981 Sep 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  403-9     Citation Subset:  IM    
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MeSH Terms
Corticosterone / secretion
Hypothalamo-Hypophyseal System / growth & development*,  physiopathology
Hypothyroidism / chemically induced,  physiopathology*
Organ Size
Pituitary-Adrenal System / growth & development*,  physiopathology
Stress, Physiological / physiopathology*
Grant Support
Reg. No./Substance:
141-90-2/Thiouracil; 50-22-6/Corticosterone

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