| Development of hyperthyroidism in a patient with idiopathic nephrotic syndrome. | |
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MedLine Citation:
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PMID: 12042896 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We present a 13-year-old boy who developed hyperthyroidism during the clinical course of idiopathic nephrotic syndrome treated with glucocorticoid. He had a second relapse of minimal change nephrotic syndrome, and complete remission of nephrotic syndrome was achieved immediately with oral glucocorticoid. However, when the steroid dosage was reduced, signs of hyperthyroidism such as systolic hypertension and tachycardia were observed. Laboratory findings revealed thyroid-stimulating hormone (TSH) below 0.05 microU/ml, free tri-iodothyronine of 16.1 pg/ml, free thyroxine of 5.6 ng/dl, and anti-TSH receptor antibody of 90%. Thus, a diagnosis of hyperthyroidism was made and treatment with thiamazol was started. Massive proteinuria may decrease the activity of hyperthyroidism due to urinary loss of thyroid hormones. A decrease in glucocorticoid dosage may also be involved in the development of hyperthyroidism due to a reduced immunosuppressive effect. |
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Authors:
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Takuo Kubota; Haruhiko Hirai; Nobuhiko Shimizu; Atsushi Sawada; Hiroki Kondou; Shigeo Nakajima; Tokuzo Harada; Masaaki Shima |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: 17 ISSN: 0931-041X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-06-03 Completed Date: 2002-07-31 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: Germany |
Other Details:
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Languages: eng Pagination: 367-9 Citation Subset: IM |
Affiliation:
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Department of Developmental Medicine (Pediatrics), D-5, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Dose-Response Relationship, Drug Drug Administration Schedule Glucocorticoids / administration & dosage, therapeutic use Humans Hyperthyroidism / complications* Male Nephrosis, Lipoid / complications*, drug therapy Prednisolone / administration & dosage, therapeutic use Recurrence Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-24-8/Prednisolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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