Document Detail


Development of the human superior colliculus and the retinocollicular projection.
MedLine Citation:
PMID:  16125175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have used carbocyanine dye tracing from the brachium of the superior colliculus in conjunction with Nissl staining and immunohistochemistry to GAP-43 and calretinin to study the development of retinal projections to the superior colliculus in 17 human embryos and fetuses aged from 8 to 28 weeks. Lamination of the superior colliculus begins to emerge by 11 weeks, and by 16 weeks all seven layers of the mature superior colliculus are visible. Fibres immunoreactive to GAP-43 were seen at 13 weeks in the most superficial layers. By 19 weeks, GAP-43 immunoreactivity was present in the stratum opticum as well as the deeper fibres layers, indicating the development of fibre pathways following those laminae. Carbocyanine dye tracing of retinocollicular projections showed extensive rostrocaudally running unbranched fibres in the superficial superior colliculus at 12 weeks. Shortly after this (13 weeks), retinocollicular fibres penetrate the deeper collicular layers and branching becomes apparent. We also saw occasional retrogradely labelled somata following DiI insertion into the superior brachium. Our findings indicate that development of the human superior colliculus and its connections is largely complete by 20 weeks. This would suggest that functional capacity of the human superior colliculus should also be mature by the middle of gestation.
Authors:
Jia Qu; Xiangtian Zhou; Hua Zhu; Gang Cheng; Ken W S Ashwell; Fan Lu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-24
Journal Detail:
Title:  Experimental eye research     Volume:  82     ISSN:  0014-4835     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-27     Completed Date:  2006-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  300-10     Citation Subset:  IM    
Affiliation:
School of Ophthalmology and Optometry, Wenzhou Medical College, 82 Xueyuan Road, Wenzhou, Zhejiang 325003, China.
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MeSH Terms
Descriptor/Qualifier:
Calcium-Binding Protein, Vitamin D-Dependent / analysis
Carbocyanines
Female
Fetal Development*
GAP-43 Protein / analysis
Humans
Immunohistochemistry / methods
Pregnancy
Pregnancy Trimester, Second
Retina / chemistry,  embryology*
Staining and Labeling
Superior Colliculi / chemistry,  embryology*
Visual Pathways*
Chemical
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Carbocyanines; 0/GAP-43 Protein; 0/calretinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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