Document Detail

Development of the human superior colliculus and the retinocollicular projection.
MedLine Citation:
PMID:  16125175     Owner:  NLM     Status:  MEDLINE    
We have used carbocyanine dye tracing from the brachium of the superior colliculus in conjunction with Nissl staining and immunohistochemistry to GAP-43 and calretinin to study the development of retinal projections to the superior colliculus in 17 human embryos and fetuses aged from 8 to 28 weeks. Lamination of the superior colliculus begins to emerge by 11 weeks, and by 16 weeks all seven layers of the mature superior colliculus are visible. Fibres immunoreactive to GAP-43 were seen at 13 weeks in the most superficial layers. By 19 weeks, GAP-43 immunoreactivity was present in the stratum opticum as well as the deeper fibres layers, indicating the development of fibre pathways following those laminae. Carbocyanine dye tracing of retinocollicular projections showed extensive rostrocaudally running unbranched fibres in the superficial superior colliculus at 12 weeks. Shortly after this (13 weeks), retinocollicular fibres penetrate the deeper collicular layers and branching becomes apparent. We also saw occasional retrogradely labelled somata following DiI insertion into the superior brachium. Our findings indicate that development of the human superior colliculus and its connections is largely complete by 20 weeks. This would suggest that functional capacity of the human superior colliculus should also be mature by the middle of gestation.
Jia Qu; Xiangtian Zhou; Hua Zhu; Gang Cheng; Ken W S Ashwell; Fan Lu
Related Documents :
8329955 - Frequency and natural history of retinopathy of prematurity (rop). a prospective study ...
23312685 - Modes of death in pediatrics: differences in the ethical approach in neonatal and pedia...
10497665 - Retinopathy of prematurity in very low birth weight infants.
16675165 - Eye-hand co-ordination skills in very preterm infants <29 weeks gestation at 3 years: e...
22034655 - Neonatal resuscitation assessment: documentation and early paging must be improved!
2863805 - The significance of thyroid-stimulating antibody (tsab) in the management and prognosti...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-24
Journal Detail:
Title:  Experimental eye research     Volume:  82     ISSN:  0014-4835     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-27     Completed Date:  2006-03-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  300-10     Citation Subset:  IM    
School of Ophthalmology and Optometry, Wenzhou Medical College, 82 Xueyuan Road, Wenzhou, Zhejiang 325003, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Calcium-Binding Protein, Vitamin D-Dependent / analysis
Fetal Development*
GAP-43 Protein / analysis
Immunohistochemistry / methods
Pregnancy Trimester, Second
Retina / chemistry,  embryology*
Staining and Labeling
Superior Colliculi / chemistry,  embryology*
Visual Pathways*
Reg. No./Substance:
0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Carbocyanines; 0/GAP-43 Protein; 0/calretinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multiple forms of 22 kDa caveolin-1 alpha present in bovine lens cells could reflect variable palmit...
Next Document:  Post-lesion transcommissural olivocerebellar reinnervation improves motor function following unilate...