Document Detail

Development of human gastrointestinal functions: interaction of changes in diet composition, hormonal maturation, and fetal genetic programming.
MedLine Citation:
PMID:  6432871     Owner:  NLM     Status:  MEDLINE    
Two aspects of the physiology of the developing gastrointestinal tract are discussed. The first one deals with functional peculiarities of the developing gastrointestinal tract. Examples are shown that less active function in the suckling (eg, low pepsin digestion in the newborn stomach) may actually give the suckling an advantage for another process. The existence of pH close to neutrality in the suckling's stomach enables "survival" of the milk and lingual lipases that are then "cooperating" with low pancreatic lipase known to be present in the sucklings. The other aspect discussed deals with the role of various factors involved in postnatal maturation of the gastrointestinal function. Using sucrase activity as an example, the important role and mutual interaction of fetal (genetic?) programming, dietary changes, and hormonal maturation are reviewed.
O Koldovský
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  3     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-02     Completed Date:  1984-10-02     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-8     Citation Subset:  IM    
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MeSH Terms
Dietary Fats / metabolism
Dietary Proteins / metabolism
Digestive System / embryology,  growth & development*
Digestive System Physiological Phenomena
Gastrointestinal Hormones / physiology*
Hydrogen-Ion Concentration
Infant Food*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Intestinal Absorption
Lactose / metabolism
Lipase / metabolism
Sucrase / metabolism
Sucrose / metabolism
beta-Galactosidase / metabolism
Reg. No./Substance:
0/Dietary Fats; 0/Dietary Proteins; 0/Gastrointestinal Hormones; 57-50-1/Sucrose; 63-42-3/Lactose; EC; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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