Document Detail


Development of the human fetal insular cortex: study of the gyration from 13 to 28 gestational weeks.
MedLine Citation:
PMID:  17962979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To describe the morphological stages of insular sulci and gyri development we carried out a macroscopical study on 21 human fetal brains, showing no anomalies, from 13 to 28 gestational weeks (GWs). Particular focus was given to morphological appearance during the development of insular and periinsular structures, especially the gyration and sulcation of the insula, central cerebral region and opercula, as well as the vascularization of these regions. The periinsular sulci and the central (insular and cerebral) sulci were the first macroscopical structures identified on the lateral surface of the human fetal cerebral hemisphere with earlier development on the right hemisphere. Here we describe five stages of insular gyral and sulcal development closely related to gestational age: stage 1: appearance of the first sulcus at 13-17 GWs, stage 2: development of the periinsular sulci at 18-19 GWs, stage 3: central sulci and opercularization of the insula at 20-22 GWs, stage 4: covering of the posterior insula at 24-26 GWs, stage 5: closure of the sylvian fissure at 27-28 GWs. We provide evidence that cortical maturation (sulcation and gyration) and vascularization of the lateral surface of the brain starts with the insular region, suggesting that this region is a central area of cortical development.
Authors:
A Afif; R Bouvier; A Buenerd; J Trouillas; P Mertens
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Publication Detail:
Type:  Journal Article     Date:  2007-10-26
Journal Detail:
Title:  Brain structure & function     Volume:  212     ISSN:  1863-2653     ISO Abbreviation:  -     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282001     Medline TA:  Brain Struct Funct     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  335-46     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Lyon-1 University, Inserm U 879, 8 avenue Rockefeller, Lyon, 69003, France.
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MeSH Terms
Descriptor/Qualifier:
Cerebral Cortex / anatomy & histology,  embryology*,  physiology*
Female
Fetal Development / physiology*
Fetus / anatomy & histology*
Gestational Age*
Humans
Pregnancy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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