Document Detail


Development of highly fluid, concentrated and stable fluorocarbon emulsions for diagnosis and therapy.
MedLine Citation:
PMID:  1391519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A challenging aim in developing injectable fluorocarbon emulsions is to combine good flow characteristics (especially at low shear rates) with the high fluorocarbon concentration required for high oxygen delivery or effective contrast in imaging, long shelf life, and biological acceptability. A good balance of these sometimes conflicting objectives has been achieved with 90% w/v concentrated emulsions of various fluorocarbons, including the radiopaque oxygen carrier perfluorooctylbromide (PFOB, perflubron). The sterile emulsions have viscosities of about 20 cPs at a shear rate of 1 sec-1; the viscosity decreases rapidly with fluorocarbon concentration, and at 60% w/v the viscosity is less than that of human blood. The emulsions are suitable for injection as prepared, and are stable unfrozen for over a year.
Authors:
J G Riess; J L Dalfors; G K Hanna; D H Klein; M P Krafft; T J Pelura; E G Schutt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology     Volume:  20     ISSN:  1055-7172     ISO Abbreviation:  Biomater Artif Cells Immobilization Biotechnol     Publication Date:  1992  
Date Detail:
Created Date:  1992-11-18     Completed Date:  1992-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111988     Medline TA:  Biomater Artif Cells Immobilization Biotechnol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  839-42     Citation Subset:  IM    
Affiliation:
Alliance Pharmaceutical Corp., San Diego, California.
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MeSH Terms
Descriptor/Qualifier:
Blood Substitutes / administration & dosage,  isolation & purification*
Drug Stability
Emulsions
Fluorocarbons / administration & dosage,  isolation & purification*
Humans
Injections
Particle Size
Viscosity
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Emulsions; 0/Fluorocarbons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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