Document Detail

Development of high blood pressure in spontaneously hypertensive rats is delayed by treatment with cyclosporin at an early age.
MedLine Citation:
PMID:  3569489     Owner:  NLM     Status:  MEDLINE    
In spontaneously hypertensive rats the effect of the T-cell inhibitor cyclosporin was studied at different ages. If treatment was started at the age of 2 weeks the development of hypertension was delayed, but the ultimate level of blood pressure was not affected. These results indicate the involvement of immune mechanisms in the early development of hypertension in spontaneously hypertensive rats.
J M Sitsen; W de Jong
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experientia     Volume:  43     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-06-01     Completed Date:  1987-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  403-5     Citation Subset:  IM    
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MeSH Terms
Aging / physiology*
Cyclosporins / pharmacology*
Hypertension / immunology*
Rats, Inbred SHR
Rats, Inbred WKY
Reg. No./Substance:

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