| Development of gut microflora in obese and lean rats. | |
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MedLine Citation:
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PMID: 20680574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence was evaluated of post-weaning normal nutrition and over-nutrition upon the development of the intestinal microbiota, the alkaline phosphatase activity (AP) and occurrence of obesity in male Sprague-Dawley rats (from days 21 to 40 the control rats were submitted to ad libitum intake of a standard laboratory diet whereas overfed rats received the same diet supplemented with milk-based high fat liquid diet). The jejunal numbers of two dominant divisions of bacteria, i.e. Firmicutes (Lactobacillus/ Enterococcus--LAB) and the Bacteroidetes (Bacteroides/Prevotella--BAC), were determined using the fluorescent in situ hybridization (FISH) method, and the jejunal AP activity was assayed histochemically. On day 40, the overfed rats in comparison with control animals displayed increased adiposity accompanied by enhanced AP activity, abundance of LAB, lower amounts of BAC and, thereafter, higher LAB/BAC ratio (L/B). The numbers of LAB and L/B index positively correlated with body fat, energy intake and AP activity, whereas numbers of BAC showed an opposite tendency. These results revealed the significance of nutritional imprint upon the post-weaning development of intestinal microbial and functional axis and contribute to better understanding of their involvement in energy-balance control and in adverse and/or positive regulation of adiposity. |
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Authors:
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Z Sefcíková; V Kmet; D Bujnáková; L Racek; S Mozes |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-03 |
Journal Detail:
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Title: Folia microbiologica Volume: 55 ISSN: 1874-9356 ISO Abbreviation: Folia Microbiol. (Praha) Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-03 Completed Date: 2010-11-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376757 Medline TA: Folia Microbiol (Praha) Country: United States |
Other Details:
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Languages: eng Pagination: 373-5 Citation Subset: IM |
Affiliation:
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Institute of Animal Physiology, Slovak Academy of Sciences, 040 01, Kosice, Slovakia. sefcikz@saske.sk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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metabolism Animals Bacteroidetes / classification*, isolation & purification* Biodiversity* Diet Gram-Positive Bacteria / classification*, isolation & purification Histocytochemistry In Situ Hybridization, Fluorescence Jejunum / enzymology, microbiology* Male Obesity / microbiology* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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