Document Detail


Development of the genital ducts and external genitalia in the early human embryo.
MedLine Citation:
PMID:  20846260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The course of development of the human genital tract is undifferentiated to the 9th week of development. At this time two symmetrical paired ducts known as the mesonephric (MD) and paramesonephric ducts (PMD) are present, which together with the urogenital sinus provide the tissue sources for internal and external genital development. Normal differentiation of the bipotential external genitalia and reproductive ducts are dependent upon the presence or absence of certain hormones. Masculinization of the internal and external genitalia during fetal development depends on the existence of two discrete testicular hormones. Testosterone secreted from Leydig cells induces the differentiation of the mesonephric ducts into the epididymis, vasa deferentia and seminal vesicles, whereas anti-Müllerian hormone (AMH) produced by Sertoli cells induces the regression of the paramesonephric ducts. The absence of AMH action in early fetal life results in the formation of the fallopian tubes, uterus and upper third of the vagina. In some target tissues, testosterone is converted to dihydrotestosterone, which is responsible for the masculinization of the urogenital sinus and external genitalia.
Authors:
Yasmin Sajjad
Publication Detail:
Type:  Journal Article; Review     Date:  2010-09-16
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  36     ISSN:  1447-0756     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-02-11     Revised Date:  2012-01-19    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  929-37     Citation Subset:  IM    
Copyright Information:
© 2010 The Author. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology.
Affiliation:
Reproductive Medicine Unit, St. Mary's Hospital Manchester, UK. y.sajjad@btinternet.com
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MeSH Terms
Descriptor/Qualifier:
Female
Genitalia / embryology*
Humans
Male
Mullerian Ducts / embryology*
Testicular Hormones
Wolffian Ducts / embryology*
Chemical
Reg. No./Substance:
0/Testicular Hormones

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