| Development of the genital ducts and external genitalia in the early human embryo. | |
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MedLine Citation:
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PMID: 20846260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The course of development of the human genital tract is undifferentiated to the 9th week of development. At this time two symmetrical paired ducts known as the mesonephric (MD) and paramesonephric ducts (PMD) are present, which together with the urogenital sinus provide the tissue sources for internal and external genital development. Normal differentiation of the bipotential external genitalia and reproductive ducts are dependent upon the presence or absence of certain hormones. Masculinization of the internal and external genitalia during fetal development depends on the existence of two discrete testicular hormones. Testosterone secreted from Leydig cells induces the differentiation of the mesonephric ducts into the epididymis, vasa deferentia and seminal vesicles, whereas anti-Müllerian hormone (AMH) produced by Sertoli cells induces the regression of the paramesonephric ducts. The absence of AMH action in early fetal life results in the formation of the fallopian tubes, uterus and upper third of the vagina. In some target tissues, testosterone is converted to dihydrotestosterone, which is responsible for the masculinization of the urogenital sinus and external genitalia. |
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Authors:
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Yasmin Sajjad |
Publication Detail:
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Type: Journal Article; Review Date: 2010-09-16 |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: 36 ISSN: 1447-0756 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-02-11 Revised Date: 2012-01-19 |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: Australia |
Other Details:
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Languages: eng Pagination: 929-37 Citation Subset: IM |
Copyright Information:
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© 2010 The Author. Journal of Obstetrics and Gynaecology Research © 2010 Japan Society of Obstetrics and Gynecology. |
Affiliation:
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Reproductive Medicine Unit, St. Mary's Hospital Manchester, UK. y.sajjad@btinternet.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Genitalia / embryology* Humans Male Mullerian Ducts / embryology* Testicular Hormones Wolffian Ducts / embryology* |
| Chemical | |
Reg. No./Substance:
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0/Testicular Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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