Document Detail

Development of gastric dysplasia in pernicious anaemia: a clinical and endoscopic follow up study of 80 patients.
MedLine Citation:
PMID:  2083855     Owner:  NLM     Status:  MEDLINE    
The development of gastric dysplasia and neoplasia in patients with pernicious anaemia has been evaluated in a prospective clinical and endoscopic follow up study. After initial screening of 80 patients between 1978 and 1980, one patient underwent total gastrectomy for a gastric malignancy and 12 were kept under surveillance and underwent endoscopy at a mean interval of 14 months. In the remaining 67 patients further investigation was attempted six to seven years after the initial investigation. The continuous follow up study identified carcinoids in one patient and an adenoma with severe dysplasia in a further patient. The grade and site of mucosal dysplasia differed from one investigation to the next, but no overall progression was observed. Of the 79 patients, eight had died by the time of the reinvestigation, two of unknown cause and six of causes unrelated to pernicious anaemia. In 38 of the remaining 71 patients, clinical data only were available, with no evidence of new gastric malignancy. In 27 patients it was possible to perform an upper gastrointestinal endoscopy, when no change in the degree of dysplasia was detected. In six patients no follow up information was obtainable. In conclusion, patients with pernicious anaemia should be investigated by upper gastrointestinal endoscopy soon after diagnosis. Polyps should be removed wherever possible. In the presence of severe mucosal dysplasia or polyps that are not removed, frequent reinvestigation should be performed, provided the patient is eligible for gastric surgery. In the remaining patients, follow up endoscopies at about five year intervals would seem sufficient.
U Armbrecht; R W Stockbrügger; J Rode; G G Menon; P B Cotton
Related Documents :
16499735 - Spontaneous regression of gastric varices after iatrogenic injury to a gastrorenal shunt.
10235315 - The relationship between helicobacter pylori infection and acid-hematuria syndrome in p...
24089235 - Association of calcium channel blocker use with lower hemoglobin levels in chronic kidn...
17883975 - Gastric electric stimulation for the treatment of gastroparesis.
25016475 - Array-cgh analysis in rwandan patients presenting development delay/ intellectual disab...
8921105 - Organ-specific autoantibodies are possible markers for reproductive failure: a prospect...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gut     Volume:  31     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-05-16     Completed Date:  1991-05-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1105-9     Citation Subset:  AIM; IM    
Department of Gastroenterology, Middlesex Hospital, London.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenoma / pathology
Anemia, Pernicious / complications*
Carcinoid Tumor / pathology
Follow-Up Studies
Middle Aged
Polyps / pathology
Precancerous Conditions / pathology*
Prospective Studies
Stomach / pathology*
Stomach Neoplasms / complications,  pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Variants of intestinal metaplasia in the evolution of chronic atrophic gastritis and gastric ulcer. ...
Next Document:  Piezoelectric lithotripsy and soft tissue injury. Safety limits in the experimental and clinical set...