Document Detail

Development of a food frequency questionnaire for the assessment of quercetin and naringenin intake.
MedLine Citation:
PMID:  17538531     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To measure the relationship between quercetin and naringenin intakes as estimated by food frequency questionnaire (FFQ), and the urinary excretion of quercetin and naringenin aglycones after their enzymatic hydrolysis in human volunteers. SUBJECTS AND METHODS: Volunteers were recruited via the Human Nutrition Unit volunteer databank at the Institute of Food Research, Norwich. Sixty-three volunteers were recruited into the study, of which 14 were excluded and 49 completed the study. A modified FFQ was developed and used to estimate daily intake of quercetin and naringenin in 49 healthy volunteers who also provided five 24-h urine samples over a 2-week period. Urinary excretion of quercetin and naringenin metabolites was determined by solid-phase extraction and high-pressure liquid chromatography. RESULTS: The estimated mean intakes of quercetin and naringenin were 29.4 mg (s.d. 15.0) and 58.1 mg (s.d. 62.7) per day, respectively. Mean urinary excretion of quercetin was 60.1 microg (s.d. 33.1) and that of naringenin was 0.56 mg (s.d. 0.4). The correlation between FFQ estimated intake of quercetin and naringenin and levels excreted in the urine were r=0.82 (P<0.0001) and r=0.25 (P=0.05), respectively. CONCLUSIONS: We observed a statistically significant correlation between the urinary excretion of quercetin and naringenin metabolites and their dietary intake as estimated by FFQ. Use of FFQs in epidemiological studies requiring an estimate of flavonoid intake seems justified.
S Ranka; J M Gee; L Biro; G Brett; S Saha; P Kroon; J Skinner; A R Hart; A Cassidy; M Rhodes; I T Johnson
Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-30
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  62     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2009-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1131-8     Citation Subset:  IM    
Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK.
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MeSH Terms
Aged, 80 and over
Diet Records
Epidemiologic Methods
Flavanones / administration & dosage*,  analysis,  urine
Middle Aged
Nutritive Value
Quercetin / administration & dosage*,  analysis,  urine
Grant Support
//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Flavanones; 117-39-5/Quercetin; 480-41-1/naringenin

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