Document Detail

Development of the fetal pituitary-adrenal axis in the sheep.
MedLine Citation:
PMID:  3072626     Owner:  NLM     Status:  MEDLINE    
In the ovine fetus, plasma levels of corticosteroids are very low between 60 and 130 days of gestation, then increase dramatically before birth. ACTH appears to be an important regulating hormone for the fetal adrenal cortex, the sensitivity of which to this hormone increases during late gestation. However, the relationship between immunoreactive ACTH and corticosteroids in the fetus is unclear. We review herein recent work performed in our laboratory on the regulation of ACTH secretion by ovine fetal pituitary cells and on the biochemical modifications responsible for the enhancement of the steroidogenic response to ACTH of fetal adrenal cells. It is suggested that qualitative together with quantitative changes in the pituitary drive to the fetal adrenal has to be taken in account to explain the rise of corticosteroids in prepartum animals. Also extra pituitary hormones may be operating during intrauterine life to regulate fetal adrenal function.
V Brieu; A M Cathiard; H Darbeida; E Naaman; J M Saez; P Durand
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Reproduction, nutrition, development     Volume:  28     ISSN:  0181-1916     ISO Abbreviation:  Reprod Nutr Dev     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-26     Completed Date:  1989-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8005903     Medline TA:  Reprod Nutr Dev     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  1129-44     Citation Subset:  IM    
I.N.R.A., Monnaie, France.
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MeSH Terms
Embryonic and Fetal Development*
Pituitary-Adrenal System / embryology*
Sheep / embryology*

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