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MedLine Citation:
PMID:  22070731     Owner:  NLM     Status:  Publisher    
Abstract Linear growth of the human fetal gastrointestinal tract is not often discussed in the literature and little is known about the effects of chromosomal abnormalities and intrauterine growth restriction (IUGR) on intestinal length, especially during the second trimester. Accurate evaluation of the intestinal length and knowledge of normal and reference values are of clinical importance. For example intestinal resection may be necessary in preterm infants with necrotizing enterocolitis or mid-gut volvulus and the surgeon should use data to be judicious in the amount removed. Linear measurements are essential in evaluating fetal development ultrasonographically and are an integral part of the postmortem examination. The intestinal lengths of 203 second trimester fetuses and premature infants were measured. Small intestine length (SIL), colon length (CL), total bowel length (TBL; TBL=SIL+CL) and the length of the appendix (AL) increased with gestational age. A table giving their predicted values and 95% confidence intervals against completed gestational weeks was constructed. No differences between the genders were observed. CL increased secondary to maceration, but no such effects were shown on SIL, TBL or AL. No differences were shown in relation to IUGR. SIL, CL and TBL, but not AL, were shorter in Trisomy-21. AL was not affected by any of the studied factors. We propose that the measurement of the length of the appendix may be used as an additional parameter for the postmortem evaluation of gestational age. Furthermore, its assessment may have the potential of an ultrasonographic indicator of gestational age, particularly for the second trimester.
Andreas Marnerides; Sam Ghazi; Anders Sundberg; Nikos Papadogiannakis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-9
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  -     ISSN:  1093-5266     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Karolinska University Hospital, Section of Perinatal Pathology, Department of Pathology/Cytology.
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