Document Detail

Development of fetal brain of 20 weeks gestational age: Assessment with post-mortem Magnetic Resonance Imaging.
MedLine Citation:
PMID:  21146341     Owner:  NLM     Status:  Publisher    
BACKGROUND: The 20th week gestational age (GA) is at mid-gestation and corresponds to the age at which the termination of pregnancy in several countries and the first Magnetic Resonance Imaging (MRI) can be performed, and at which the premature babies may survive. However, at present, very little is known about the exact anatomical character at this GA. OBJECTIVE: To delineate the developing fetal brain of 20 weeks GA and obtain the three dimensional visualization model. MATERIALS AND METHODS: 20 fetal specimens were scanned by 3.0T and 7.0T post-mortem MRI, and the three dimensional visualization model was obtained with Amira 4.1. RESULTS: Most of the sulci or their anlage, except the postcentral sulcus and intraparietal sulcus, were present. The laminar organization, described as layers with different signal intensities, was most clearly distinguished at the parieto-occipital lobe and peripheral regions of the hippocampus. The basal nuclei could be clearly visualized, and the brain stem and cerebellum had formed their common shape. On the visualization model, the shape and relative relationship of the structures could be appropriately delineated. The ranges of normal values of the brain structures were obtained, but no sexual dimorphisms or cerebral asymmetries were found. CONCLUSIONS: The developing fetal brain of 20 weeks GA can be clearly delineated on 3.0T and 7.0T post-mortem MRIs, and the three dimensional visualization model supplies great help in precise cognition of the immature brain. These results may have positive influences on the evaluation of the fetal brain in the uterus.
Zhonghe Zhang; Shuwei Liu; Xiangtao Lin; Gaojun Teng; Taifei Yu; Fang Fang; Fengchao Zang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-9
Journal Detail:
Title:  European journal of radiology     Volume:  -     ISSN:  1872-7727     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier Ireland Ltd. All rights reserved.
Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 44 Wen-hua Xi Road, 250012 Jinan, Shandong, China.
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