| Development of fatty acid-synthetic capacity in interscapular brown adipose tissue during suckling in genetically obese Zucker rats. | |
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MedLine Citation:
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PMID: 6141788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of the lipogenic capacity in brown adipose tissue was studied in suckling lean (Fa/fa) and obese (fa/fa) Zucker pups aged from 7 to 22 days. In both lean and obese pups, activities of the two key lipogenic enzymes, fatty acid synthetase and acetyl-CoA carboxylase, and of citrate cleavage enzyme rose from the early to the late suckling period. Compared with lean pups, 7-day-old fa/fa pups showed a 35% increase in fat accumulation in interscapular brown adipose tissue and a 25% increase in fatty acid synthetase activity. By 10 days of age, fat deposition, lipogenesis in vivo (assessed by the incorporation of 3H from 3H2O into fatty acids) and fatty acid synthetase activity were 1.5-2-fold higher in pre-obese than in lean pups. Compared with lean pups, the increased lipogenesis in vivo observed in brown adipose tissue of 10-day-old pre-obese pups could not entirely account for the difference in fat deposition observed in this tissue, suggesting that additional mechanisms are at play to explain the increased fat content of this tissue. |
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Authors:
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R Bazin; M Lavau; C Guichard |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Biochemical journal Volume: 216 ISSN: 0264-6021 ISO Abbreviation: Biochem. J. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-03-06 Completed Date: 1984-03-06 Revised Date: 2010-09-10 |
Medline Journal Info:
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Nlm Unique ID: 2984726R Medline TA: Biochem J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 543-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetyl-CoA Carboxylase
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metabolism Adipose Tissue, Brown / enzymology, metabolism* Animals Animals, Suckling Citrates / metabolism Fatty Acid Synthetase Complex / metabolism Fatty Acids / biosynthesis* Female Lipid Metabolism Male Obesity / metabolism* Rats Rats, Zucker |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Fatty Acids; EC 6.-/Fatty Acid Synthetase Complex; EC 6.4.1.2/Acetyl-CoA Carboxylase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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