Document Detail

Development of fat digestion in infancy.
MedLine Citation:
PMID:  10212078     Owner:  NLM     Status:  MEDLINE    
AIM: To measure the development of fat digestion in early life, using a stable isotope breath test. METHODS: A combined longitudinal and cross sectional study was performed on 30 term and preterm infants using 13C-labelled mixed triglyceride (MTG). Seventy six tests were performed in all. Results were expressed as cumulative percentage dose recovered over 6 hours (cPDR). RESULTS: Eighteen of 34 tests performed on infants under 30 days of age showed cPDRs below the normal range for adults and older children. The remainder of tests, performed on infants over 57 days of age, all showed cPDRs within the normal range. Peak PDR correlated significantly (r = 0. 928, p<0.01) with cPDR. CONCLUSION: The capacity to digest fat is incomplete at birth, but quickly develops to normal levels during the first months of life. The MTG breath test is a useful non-invasive method to measure the development of fat digestion in early life.
W G Manson; W A Coward; M Harding; L T Weaver
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  80     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  1999 May 
Date Detail:
Created Date:  2000-03-29     Completed Date:  2000-03-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  F183-7     Citation Subset:  AIM; IM    
Department of Child Health, University of Glasgow, Yorkhill Hospitals, Glasgow, UK.
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MeSH Terms
Breath Tests
Carbon Isotopes
Cross-Sectional Studies
Dietary Fats / metabolism*
Infant, Newborn / growth & development*,  metabolism
Intestines / growth & development*,  metabolism
Longitudinal Studies
Triglycerides / diagnostic use
Reg. No./Substance:
0/Carbon Isotopes; 0/Dietary Fats; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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