| Development and evaluation of tetrapod-shaped granular artificial bones. | |
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MedLine Citation:
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PMID: 22387335 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have developed a novel form of granular artificial bones "Tetrabones" with a homogeneous tetrapod-shape and uniform size. Tetrabones are four-legged structures that accumulate to form the intergranular pores that allow invasion of cells and blood vessels. In this study, we evaluated the physicochemical characteristics of Tetrabonesin vitro, and compared their biological and biomechanical propertiesin vivo to those of conventional β-tricalcium phosphate (β-TCP) granule artificial bones. Both the rupture strength and elastic modulus of Tetrabone particles were higher than those of β-TCP granules in vitro. The connectivity of intergranular pores with sizes 100, 300, and 400 μm were higher in Tetrabones than in the β-TCP granules. Tetrabones showed properosteoconductivity and biomechanical stiffness to β-TCP at 2 months after implantation in an in vivo study of canine bone defects. These results suggest that Tetrabones may be a good bone graft material in bone reconstruction. |
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Authors:
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Sungjin Choi; Ili Liu; Kenichi Yamamoto; Kazuyo Igawa; Manabu Mochizuki; Takamasa Sakai; Echigo Ryosuke; Muneki Honnami; Shigeki Suzuki; Ung-Il Chung; Nobuo Sasaki |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-1 |
Journal Detail:
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Title: Acta biomaterialia Volume: - ISSN: 1878-7568 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ltd. |
Affiliation:
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Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. |
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