Document Detail


Development and evaluation of a novel ultrasound score for large joints in rheumatoid arthritis: One year experience in daily clinical practice.
MedLine Citation:
PMID:  22183834     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE.: To introduce and evaluate a new standardized ultrasound (US) score developed for large joints in patients with rheumatoid arthritis (RA). METHODS.: An US score was designed to determine the degree of inflammation in the shoulder, the elbow, the hip and the knee joint in patients suffering from RA (Sonography of Large Joints in Rheumatology, SOLAR). Synovitis and synovial vascularity were scored semiquantitatively (grade 0-3) by grey scale (GSUS) and power Doppler ultrasound (PDUS). RA patients were examined at baseline and 3, 6 and 12 months after initiation of local or systemic therapy (DMARDs / biologics). Erythrocyte sedimentation rate, anti - citrullinated peptide antibodies and the clinical Disease Activity (DAS28) were determined. RESULTS.: A cohort of 199 patients was analyzed, which have been followed over 12 months. At baseline,before modification of the therapy, patients received DMARDs (n = 131), DMARDs plus biologics (n = 46), biologic monotherapy (n = 8) or no DMARD therapy (n = 14). At baseline, the mean DAS28 was 4.6 and decreased to 3.3 after one year of therapy (p < 0.001). All US scores demonstrated a statistically significant improvement except the PDUS scores for the shoulder and the hip. In detail, the mean synovitis score in GSUS for the knee decreased from 5.2 at baseline to 2.2 after 12 months of follow up. For the shoulder GSUS score fell from 2.6 to 1.6, the elbow score from 5.2 to 2.6 and the mean hip GSUS score declined from 2.2 to 0.4 respectively (each p < 0.05). CONCLUSION.: The SOLAR score is a feasible tool for the qualitative and quantitative evaluation of large joint involvement in RA patients using US. © 2011 American College of Rheumatology.
Authors:
Herbert Kellner; Johannes Strunk; Horst Sattler; Wolfgang A Schmidt; Boris Ehrenstein; Martin Fleck; Marina Backhaus
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-19
Journal Detail:
Title:  Arthritis care & research     Volume:  -     ISSN:  2151-4658     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Affiliation:
Hospital Neuwittelsbach, Romanstraße 9, D-80639 München, Germany.
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