Document Detail


Development and evaluation of nifedipine controlled release tablets prepared using mucoadhesive swellable polymer.
MedLine Citation:
PMID:  20954856     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Nifedipine is embedded in Gelcarin GP-379 to develop a prolonged release matrix. The effect of polymers levels (15, 20, 30 and 50% w/w), diluent type (lactose Fast Flo, DiTab, and Avicel PH-101), and drug levels (13, 20 and 30% w/w) on in vitro release rate of the drug were investigated. The formulation containing 13% nifedipine, 20% Gelcarin GP-379, and lactose Fast Flo controlled the dissolution rate of nifedipine and released approximately 51% drug at 8 h of testing dissolution. The use of different types of diluents, different drug levels, and different rotational speeds during dissolution testing did affect the drug release rate from the swellable matrices. The dissolution data were analyzed according to Higuchi model, zero order, first order, and Peppas kinetic model. Drug release was found to follow the anomalous diffusion model for swellable matrix.
Authors:
W A Felician; E S Ghaly
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Publication Detail:
Type:  Journal Article     Date:  2010-10-18
Journal Detail:
Title:  Pharmaceutical development and technology     Volume:  16     ISSN:  1097-9867     ISO Abbreviation:  Pharm Dev Technol     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610932     Medline TA:  Pharm Dev Technol     Country:  England    
Other Details:
Languages:  eng     Pagination:  536-41     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, San Juan, Puerto Rico.
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