| Development and estimation of a novel cryoprobe utilizing the Peltier effect for precise and safe cryosurgery. | |
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MedLine Citation:
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PMID: 19723517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have developed a novel cryoprobe for skin cryosurgery utilizing the Peltier effect. The four most important parameters for necrotizing tissue efficiently are the cooling rate, end temperature, hold time and thawing rate. In cryosurgery for small skin diseases such as flecks or early carcinoma, it is also important to control the thickness of the frozen region precisely to prevent necrotizing healthy tissue. To satisfy these exacting conditions, we have developed a novel cryoprobe to which a Peltier module was attached. The cryoprobe makes it possible to control heat transfer to skin surface precisely using a proportional-integral-derivative (PID) controller, and because it uses the Peltier effect, the cryoprobe does not need to move during the operation. We also developed a numerical simulation method that allows us to predict the frozen region and the temperature profile during cryosurgery. We tested the performance of our Peltier cryoprobe by cooling agar, and the results show that the cryoprobe has sufficient cooling performance for cryosurgery, because it can apply a cooling rate of more than 250 degrees C/min until the temperature reaches -40 degrees C. We also used a numerical simulation to reconstruct the supercooling phenomenon and examine the immediate progress of the frozen region with ice nucleation. The calculated frozen region was compared with the experimentally measured frozen region observed by an interferometer, and the calculation results showed good agreement. The results of numerical simulation confirmed that the frozen region could be predicted accurately with a margin of error as small as 150 microm during use of the cryoprobe in cryosurgery. The numerical simulation also showed that the cryoprobe can control freezing to a depth as shallow as 300 microm. |
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Authors:
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Hiroki Takeda; Shigenao Maruyama; Junnosuke Okajima; Sestuya Aiba; Atsuki Komiya |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Validation Studies Date: 2009-08-31 |
Journal Detail:
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Title: Cryobiology Volume: 59 ISSN: 1090-2392 ISO Abbreviation: Cryobiology Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-30 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006252 Medline TA: Cryobiology Country: United States |
Other Details:
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Languages: eng Pagination: 275-84 Citation Subset: IM |
Affiliation:
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School of Engineering, Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai, Miyagi 980-8577, Japan. heroki@pixy.ifs.tohoku.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Computer Simulation Cryosurgery / instrumentation* Cryotherapy / instrumentation Models, Biological Skin / surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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