| Development of equine models of inflammation. The Ciba-Geigy Prize for Research in Animal Health. | |
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MedLine Citation:
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PMID: 2823447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two experimental models of acute non-immune inflammation have been developed to enable studies of the biochemical composition and cellular content of exudates to be undertaken. Both are based on the creation of a mild, reproducible and reversible inflammatory reaction, which is free from uncontrolled incidental factors and which causes minimal distress to the experimental animals. The polyester sponge model involves the insertion of small polyester sponge strips soaked in sterile carrageenan solution into subcutaneous neck pouches and their serial removal. The tissue-cage model is based on the initial insertion of a spherical tissue-cage subcutaneously in the neck and the subsequent stimulation with carrageenan of the granulation tissue which lines and permeates the cage. The acute inflammatory exudates have been shown to contain eicosanoids with prostaglandin E2 predominant. Polymorphonuclear leucocyte numbers increased progressively in the polyester sponge model, whereas cell numbers were maximal at 12 hours in the tissue-cage model. The relationships between eicosanoid formation at the site of inflammation and leucocyte accumulation, enzyme release, total protein content of exudates and the temperature of the lesions have been investigated. |
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Authors:
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A J Higgins; P Lees; A D Sedgwick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Veterinary record Volume: 120 ISSN: 0042-4900 ISO Abbreviation: Vet. Rec. Publication Date: 1987 May |
Date Detail:
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Created Date: 1987-11-25 Completed Date: 1987-11-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0031164 Medline TA: Vet Rec Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 517-22 Citation Subset: IM |
Affiliation:
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Animal Health Trust, Newmarket, Suffolk. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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analysis Animals Carrageenan Dinoprostone Disease Models, Animal* Exudates and Transudates / analysis Horse Diseases / physiopathology* Horses Inflammation / physiopathology, veterinary* Leukotriene B4 / analysis Prostaglandins E / analysis Proteins / analysis Thromboxane B2 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 0/Proteins; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4; 9000-07-1/Carrageenan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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